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Trials have shown that tigecycline is capable of killing almost all of the (ESBLs) and multidrug resistant () isolates and the large majority of ESBL and MDR isolates of species.
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In ciprofloxacin-selected S aureus mutants, the first mutation identified was in parC.
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The upside is that we now know that this route is to be avoided for the time being; however, it is probable that in the long run, genomic information will prove to be highly useful to antibiotic discovery, but perhaps not in the way originally envisioned, as a short cut to target selection.
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